Atomic Structures of Coxsackievirus B5 Provide Key Information on Viral Evolution and Survival

Author:

Yang Peng12,Shi Dawei3,Fu Jianmeng12,Zhang Li4,Chen Ruihong1,Zheng Binyang4,Wang Xiangxi1,Xu Sihong3,Zhu Ling1,Wang Kang1ORCID

Affiliation:

1. Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

2. University of Chinese Academy of Sciences, Beijing, China

3. Institute for In Vitro Diagnostics Control, National Institutes for Food and Drug Control, Beijing, China

4. National Health Commission of the People’s Republic of China, Key Laboratory of Enteric Pathogenic Microbiology (Jiangsu Provincial Center for Disease Control and Prevention), Nanjing, China

Abstract

As one of the main serotypes in Enterovirus B, CVB5 has been commonly reported in recent years. The atomic structures of CVB5 shown here revealed classical features found in EV-Bs and the structural rearrangement occurring during particle expansion and uncoating.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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