Lyon IARC Polyomavirus Displays Transforming Activities in Primary Human Cells

Author:

Venuti Assunta1,Romero-Medina Maria Carmen1,Melita Giusi1,Ceraolo Maria Grazia1,Brancaccio Rosario Nicola1,Sirand Cecilia1,Taverniti Valerio1,Steenbergen Renske2,Gheit Tarik1ORCID,Tommasino Massimo3ORCID

Affiliation:

1. International Agency for Research on Cancer (IARC), World Health Organization, Lyon Cedex, France

2. VU University Medical Center Amsterdam, Department of Pathology, Amsterdam, The Netherlands

3. IRCCS Istituto Tumori Giovanni Paolo II, Bari, Italy

Abstract

Lyon IARC PyV is a recently discovered polyomavirus that shows some structural similarities to well-established animal and human oncogenic PyVs, such as raccoon PyV and Merkel cell PyV, respectively. Here, we show the capability of LIPyV to efficiently promote cellular transformation of primary human cells, suggesting a possible oncogenic role of this virus in domestic animals and/or humans.

Funder

Fondation ARC pour la Recherche sur le Cancer

Institut National de la Santé et de la Recherche Médicale

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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