Merkel cell polyomavirus and Merkel cell carcinoma-Reference-Cited by-同舟云学术

Merkel cell polyomavirus and Merkel cell carcinoma

Published:2017-09-11 Issue:1732 Volume:372 Page:20160276
ISSN:0962-8436
Container-title:Philosophical Transactions of the Royal Society B: Biological Sciences
language:en
Short-container-title:Phil. Trans. R. Soc. B

Author:

DeCaprio James A.¹²^ORCID

Affiliation:

1. Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA

2. Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA

Abstract

Merkel cell polyomavirus (MCPyV) causes the highly aggressive and relatively rare skin cancer known as Merkel cell carcinoma (MCC). MCPyV also causes a lifelong yet relatively innocuous infection and is one of 14 distinct human polyomaviruses species. Although polyomaviruses typically do not cause illness in healthy individuals, several can cause catastrophic diseases in immunocompromised hosts. MCPyV is the only polyomavirus clearly associated with human cancer. How MCPyV causes MCC and what oncogenic events must transpire to enable this virus to cause MCC is the focus of this essay. This article is part of the themed issue ‘Human oncogenic viruses’.

Funder

Claudia Adams Barr Program in Cancer Research

DFCI Helen Pappas Merkel Cell Research Fund

U.S. Public Health Service

Publisher

The Royal Society

Subject

General Agricultural and Biological Sciences,General Biochemistry, Genetics and Molecular Biology

Link

https://royalsocietypublishing.org/doi/pdf/10.1098/rstb.2016.0276

Reference120 articles.

1. Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma