Increased Proviral DNA in Circulating Cells Correlates with Plasma Viral Rebound in Simian Immunodeficiency Virus-Infected Rhesus Macaques after Antiretroviral Therapy Interruption-Reference-Cited by-同舟云学术

Increased Proviral DNA in Circulating Cells Correlates with Plasma Viral Rebound in Simian Immunodeficiency Virus-Infected Rhesus Macaques after Antiretroviral Therapy Interruption

Published:2021-02-24 Issue:6 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Ziani Widade¹,Shao Jiasheng¹,Wang Xiaolei¹,Russell-Lodrigue Kasi¹,Liu Yao-Zhong²,Montaner Luis J.³,Veazey Ronald S.¹,Xu Huanbin¹^ORCID

Affiliation:

1. Tulane National Primate Research Center, Tulane University School of Medicine, Covington, Louisiana, USA

2. Department of Biostatistics and Data Science, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA

3. The Wistar Institute, Philadelphia, Pennsylvania, USA

Abstract

Viral reservoirs are involved in persistent HIV infection, and a small number of mosaic latent cellular reservoirs promote viral rebound upon analytical treatment interruption, which is the major obstacle to a cure. However, early indicators that can predict resurgence of viremia after treatment interruption may aid treatment decisions in people living with HIV.

Funder

Carol Lavin Bernick Foundation

Robert I. Jacobs Fund

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Center for Research Resources

HHS | NIH | National Institute of Dental and Craniofacial Research

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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