Comparative in vitro antimicrobial susceptibilities of a special panel of 74 Bacteroides fragilis group isolates in Wilkins-Chalgren agar with and without sheep blood

Author:

Gill C J1,Shungu D L1,Ponticas S1

Affiliation:

1. Clinical Microbiology Services, Merck and Co., Inc., Rahway, New Jersey 07065.

Abstract

Seventy-four cefoxitin-resistant Bacteroides fragilis group isolates were tested by the serial twofold agar dilution method for susceptibility to imipenem and other agents in medium with and without 5% sheep blood. Imipenem (MIC for 90% of strains tested, 1 microgram/ml) and metronidazole (MIC for 90% of strains tested, 2 micrograms/ml) were the two most active agents. The addition of 5% sheep blood to the medium had little or no effect on the activity of the antibiotics tested.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference7 articles.

1. National Committee for Clinical Laboratory Standards agar dilution susceptibility testing of anaerobic gramnegative bacteria;Brown W. J.;Antimicrob. Agents Chemother.,1988

2. In vitro susceptibility of the Bacteroides fragilis group in community hospitals;File T. M. Jr.;Diagn. Microbiol. Infect. Dis.,1986

3. Comparative antimicrobial activity of aminothiazolyl methoxyimino cephalosporins against anaerobic bacteria, including 100 cefoxitin-resistant isolates;Jones R. N.;Diagn. Microbiol. Infect. Dis.,1987

4. National Committee for Clinical Laboratory Standards. 1985. Referencesgar dilution procedure for antimicrobial susceptibility testing of anaerobic bacteria. Approved standard. Publication Mll-A. National Committee for Clinical Laboratory Standards Villanova Pa.

5. Activity of newer 1-lactam agents against clinical isolates of Bacteroides fragilis and other Bacteroides species;O'Keefe J. P.;Antimicrob. Agents Chemother.,1987

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