Activity of newer beta-lactam agents against clinical isolates of Bacteroides fragilis and other Bacteroides species

Author:

O'Keefe J P1,Venezio F R1,DiVincenzo C A1,Shatzer K L1

Affiliation:

1. Infectious Disease Research Laboratory, Loyola University Medical Center, Maywood, Illinois 60153.

Abstract

The in vitro activities of beta-lactam antibiotics against Bacteroides fragilis and B. fragilis group isolates are presented. Clinical isolates from 1986 were compared with strains from 1979 to 1982. Imipenem, ticarcillin-clavulanic acid, and ceftizoxime were the most active agents. Cefotetan was equivalent to cefoxitin against B. fragilis but less active against B. fragilis group isolates. Enhancement of cefotaxime by its desacetyl metabolite was minimal.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference13 articles.

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4. Clinical pharmacokinetics of cefotaxime in patients with normal and reduced renal function;Doluisio J. T.;Rev. Infect. Dis.,1982

5. Activity of cefazolin and two P-lactamase inhibitors, clavulanic acid and sulbactam, against Bacteroides fragilis;Fekete T.;Antimicrob. Agents Chemother.,1987

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