Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161-Reference-Cited by-同舟云学术

Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161

Published:2019-01 Issue:1 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Monk Brian C.¹,Keniya Mikhail V.¹,Sabherwal Manya¹,Wilson Rajni K.¹,Graham Danyon O.¹,Hassan Harith F.¹,Chen Danni¹,Tyndall Joel D. A.²

Affiliation:

1. Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand

2. School of Pharmacy, University of Otago, Dunedin, New Zealand

Abstract

Tetrazole antifungals designed to target fungal lanosterol 14α-demethylase (LDM) appear to be effective against a range of fungal pathogens. In addition, a crystal structure of the catalytic domain of Candida albicans LDM in complex with the tetrazole VT-1161 has been obtained.

Funder

Manatu Hauora | Health Research Council of New Zealand

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02114-18

Reference49 articles.

1. Outwitting Multidrug Resistance to Antifungals

2. The global problem of antifungal resistance: prevalence, mechanisms, and management

3. Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals