Design and optimization of highly-selective fungal CYP51 inhibitors

Author:

Hoekstra William J.,Garvey Edward P.,Moore William R.,Rafferty Stephen W.,Yates Christopher M.,Schotzinger Robert J.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference16 articles.

1. Crystal structure of cytochrome P450 14 -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors

2. Current Concepts in Antifungal Pharmacology

3. Addressing current medical needs in invasive fungal infection prevention and treatment with new antifungal agents, strategies and formulations

4. Schotzinger, R.J.; Degenhardt, T.P.; Wargin, W.A.; Still, J.G.; Gutierrez, M.J. ‘A Phase 1 Multiple-Ascending-Dose Trial of VT-1161, a Highly Potent and Selective Oral Antifungal Agent for the Treatment of Superficial Fungal Infections’. Abstract #7516, Am. Acad. Dermatology Summer Academy Meeting, August 2, 2013.

5. Novel antifungal 2-aryl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol derivatives with high activity against Aspergillus fumigatus

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