l -Alanine Auxotrophy of Lactobacillus johnsonii as Demonstrated by Physiological, Genomic, and Gene Complementation Approaches-Reference-Cited by-同舟云学术

l -Alanine Auxotrophy of Lactobacillus johnsonii as Demonstrated by Physiological, Genomic, and Gene Complementation Approaches

Published:2004-03 Issue:3 Volume:70 Page:1869-1873
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

van der Kaaij Hengameh¹,Desiere Frank¹,Mollet Beat¹,Germond Jacques-Edouard¹

Affiliation:

1. Nestlé Research Centre, Nestec, Ltd., CH-1000 Lausanne 26, Switzerland

Abstract

ABSTRACT Using a chemically defined medium without l -alanine, Lactobacillus johnsonii was demonstrated to be strictly auxotrophic for that amino acid. A comparative genetic analysis showed that all known genes involved in l -alanine biosynthesis are absent from the genome of L. johnsonii . This auxotrophy was complemented by heterologous expression of the Bacillus subtilis l -alanine dehydrogenase.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.70.3.1869-1873.2004

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