A Survey of Helicobacter pylori Antibiotic-Resistant Genotypes and Strain Lineages by Whole-Genome Sequencing in China

Author:

Zhou Yan12,Zhong Zishao3456ORCID,Hu Shengjuan12,Wang Jing5,Deng Yanhong2,Li Ximei12,Chen Xianmei2,Li Xue2,Tang Yuanyuan2,Li Xiaofei2,Hao Qian2,Liu Jun2,Sang Tian2,Bo Yang17,Bai Feihu89ORCID

Affiliation:

1. The Third School of Clinical Medicine, Ningxia Medical University, Yinchuan, China

2. Department of Gastroenterology, Endoscopic center, People’s Hospital of Ningxia Hui Autonomous Region, Yinchuan, China

3. Tongji Hospital, School of Medicine, Tongji University, Shanghai, China

4. Institute of Digestive Disease, School of Medicine, Tongji University, Shanghai, China

5. Department of Gastroenterology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China

6. China Center for Helicobacter Pylori Molecular Medicine, Shanghai, China

7. Department of Hepatobiliary Surgery, People’s Hospital of Ningxia Hui Autonomous Region, Yinchuan, China

8. Department of Gastroenterology, The Second Affiliated Hospital of Hai Nan Medical College, Haikou, China

9. The Gastroenterology Clinical Medical Center of Hainan Province, Haikou, China

Abstract

Antibiotic resistance is the most important factor leading to failed Helicobacter pylori eradication therapy, and personalized treatment based on antibiotic susceptibility is becoming increasingly important. To strengthen the understanding of antibiotic genotypic resistance of H. pylori and identify new antibiotic resistance loci, in this study, we identified phenotypic resistance information for 60 clinical isolates and compared the concordance of phenotypic and genotypic resistance using whole-genome sequencing (WGS).

Funder

Science and Technology Department of Ningxia

China Postdoctoral Science Foundation

National Natural Science Foundation of China

Hainan Provincial Health and Family Planning Commission

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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