Human Blastomycosis in South Africa Caused by Blastomyces percursus and Blastomyces emzantsi sp. nov., 1967 to 2014

Author:

Maphanga Tsidiso G.12ORCID,Birkhead Monica1ORCID,Muñoz José F.3ORCID,Allam Mushal1ORCID,Zulu Thokozile G.1,Cuomo Christina A.3ORCID,Schwartz Ilan S.4,Ismail Arshad1ORCID,Naicker Serisha D.15,Mpembe Ruth S.1,Corcoran Craig6,de Hoog Sybren78,Kenyon Chris9,Borman Andrew M.10,Frean John A.15,Govender Nelesh P.15ORCID

Affiliation:

1. National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa

2. University of the Free State, Bloemfontein, South Africa

3. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA

4. University of Alberta, Edmonton, Alberta, Canada

5. University of the Witwatersrand, Johannesburg, South Africa

6. Ampath National Laboratory Service, Johannesburg, South Africa

7. Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands

8. Center of Expertise in Mycology of RadboudUMC/Canisius Wilhelmina Hospital, Nijmegen, The Netherlands

9. Institute of Tropical Medicine, Antwerp, Belgium

10. UK National Mycology Reference Laboratory, Public Health England, Bristol, United Kingdom

Abstract

We reevaluated 20 cases of blastomycosis diagnosed in South Africa between 1967 and 2014, with Blastomyces dermatitidis considered to be the etiological agent, in light of newly described species and the use of more advanced technologies. In addition to histopathological and/or culture-based methods, all 20 isolates were phenotypically and genotypically characterized, including multilocus typing of five genes and whole-genome sequencing.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference50 articles.

1. Protozoan dermatitis;Gilchrist TC;J Cutan Gen Dis,1894

2. Blastomycosis in Africa: a new case from Tunisia;Jerray M;Eur Respir J,1992

3. Blastomycosis in Africa

4. Blastomyces dermatitidis infections in the RSA;Frean JA;S Afr Med J,1989

5. Novel taxa of thermally dimorphic systemic pathogens in theAjellomycetaceae(Onygenales)

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