Antifungal pharmacodynamic characteristics of fluconazole and amphotericin B tested against Candida albicans

Author:

Klepser M E1,Wolfe E J1,Jones R N1,Nightingale C H1,Pfaller M A1

Affiliation:

1. College of Pharmacy, University of Iowa, Iowa City 52242-1112, USA. michael-klepser@uiowa.edu

Abstract

Time-kill curves were determined for three isolates of Candida albicans tested against fluconazole and amphotericin B at multiples of the MIC. Fluconazole produced fungistatic activity, with concentration-related growth effects observed over a narrow range of concentrations. Amphotericin B exhibited fungicidal activity, with enhancement of activity over a broader range of concentrations.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference8 articles.

1. Banerjee S. N. T. G. Emori D. H. Culver R. P. Gaynes W. R. Jones T. Horan et al. 1991. Secular trends in nosocomial primary blood stream infections in the United States 1980-1989. Am. J. Med. 91(Suppl. 3B):86S-89S.

2. Pharmacokinetics of 18F-labeled fluconazole in healthy human subjects by positron emission tomography;Fischman A. J.;Antimicrob. Agents Chemother.,1993

3. Klepser M. E. E. J. Wolfe and M. A. Pfaller. 1996. Characterization of the fungicidal dynamics of fluconazole (FLU) and amphotericin B (AB) against Cryptococcus neoformans via kill-curve methodologies abstr. 77 p. 50. In Program and Abstracts of the 34th Annual Meeting of the Infectious Diseases Society of America.

4. .Klepser M. E. E. J. Wolfe R. N. Jones C. H. Nightingale and M. A. Pfaller. 1996. Characterization of the fungicidal dynamics of fluconazole (FLU) and amphotericin B (AB) against C. albicans via kill-curve methodologies abstr. E51 p. 90. In Abstracts of the 36th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology Washington D.C.

5. National Committee for Clinical Laboratory Standards. 1995. Reference method for broth dilution antifungal susceptibility testing for yeasts. Proposed standard M27-T. National Committee for Clinical Laboratory Standards Villanova Pa.

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