Comparison of Cefepime-Cefpirome and Carbapenem Therapy for Acinetobacter Bloodstream Infection in a Multicenter Study-Reference-Cited by-同舟云学术

Comparison of Cefepime-Cefpirome and Carbapenem Therapy for Acinetobacter Bloodstream Infection in a Multicenter Study

Published:2020-05-21 Issue:6 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chang Yea-Yuan¹²³⁴⁵,Yang Ya-Sung⁶,Wu Shang-Liang⁷,Wang Yung-Chih⁶,Chen Te-Li³⁸,Lee Yi-Tzu³⁴⁹

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, National Yang-Ming University Hospital, Yilan, Taiwan

2. Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan

3. Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

4. Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan

5. Division of Infectious Diseases, Department of Internal Medicine, Taipei City Hospital Renai Branch, Taipei, Taiwan

6. Division of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan

7. School of Medicine, Griffith University, Gold Coast Campus, Southport, Queensland, Australia

8. Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan

9. Department of Emergency Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

Abstract

Carbapenems are currently the preferred agents for the treatment of serious Acinetobacter infections. However, whether cefepime-cefpirome can be used to treat an Acinetobacter bloodstream infection (BSI) if it is active against the causative pathogen(s) is not clear. This study aimed to compare the efficacy of cefepime-cefpirome and carbapenem monotherapy in patients with Acinetobacter BSI. The population included 360 patients with monomicrobial Acinetobacter BSI receiving appropriate antimicrobial therapy admitted to four medical centers in Taiwan in 2012 to 2017.

Funder

National Defense Medical Center

Ministry of Science and Technology, Taiwan

Taipei Veterans General Hospital

National Yang-Ming University

Tri-Service General Hospital

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02392-19