Relationship between Plasma and Intracellular Concentrations of Bedaquiline and Its M2 Metabolite in South African Patients with Rifampin-Resistant Tuberculosis-Reference-Cited by-同舟云学术

Relationship between Plasma and Intracellular Concentrations of Bedaquiline and Its M2 Metabolite in South African Patients with Rifampin-Resistant Tuberculosis

Published:2021-10-18 Issue:11 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ngwalero Precious¹,Brust James C. M.²,van Beek Stijn W.³,Wasserman Sean⁴⁵^ORCID,Maartens Gary¹⁴⁵^ORCID,Meintjes Graeme⁴⁵,Joubert Anton¹,Norman Jennifer¹,Castel Sandra¹,Gandhi Neel R.⁶,Denti Paolo¹^ORCID,McIlleron Helen¹⁴⁵^ORCID,Svensson Elin M.³⁷,Wiesner Lubbe¹^ORCID

Affiliation:

1. Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

2. Albert Einstein College of Medicine & Montefiore Medical Center, Bronx, New York, USA

3. Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

4. Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa

5. Department of Medicine, University of Cape Town, Cape Town, South Africa

6. Rollins School of Public Health and Emory School of Medicine, Emory University, Atlanta, Georgia, USA

7. Department of Pharmacy, Uppsala University, Uppsala, Sweden

Abstract

Bedaquiline is recommended for the treatment of all patients with rifampin-resistant tuberculosis (RR-TB). Bedaquiline accumulates within cells, but its intracellular pharmacokinetics have not been characterized, which may have implications for dose optimization.

Funder

AIDS Clinical Trials Group

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02399-20

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