New Mutation in ParE in a Pneumococcal In Vitro Mutant Resistant to Fluoroquinolones-Reference-Cited by-同舟云学术

New Mutation in ParE in a Pneumococcal In Vitro Mutant Resistant to Fluoroquinolones

Published:2001-03 Issue:3 Volume:45 Page:952-955
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Janoir Claire¹,Varon Emmanuelle¹,Kitzis Marie-Dominique²,Gutmann Laurent¹

Affiliation:

1. L.R.M.A., Université Paris VI, 75270 Paris Cedex 06,1 and

2. Service de Bactériologie, Hôpital Saint-Joseph, 75674 Paris Cedex 14,2 France

Abstract

ABSTRACT For an in vitro mutant of Streptococcus pneumoniae selected on moxifloxacin four- to eightfold-increased MICs of new fluoroquinolones, only a twofold-increased MIC of ciprofloxacin, and a twofold-decreased MIC of novobiocin were observed. This phenotype was conferred by two mutations: Ser81Phe in GyrA and a novel undescribed His103Tyr mutation in ParE, outside the quinolone resistance-determining region, in the putative ATP-binding site of topoisomerase IV.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.45.3.952-955.2001

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