Multicenter Evaluation of an MIC-Based Aztreonam and Ceftazidime-Avibactam Broth Disk Elution Test-Reference-Cited by-同舟云学术

Multicenter Evaluation of an MIC-Based Aztreonam and Ceftazidime-Avibactam Broth Disk Elution Test

Published:2023-05-23 Issue:5 Volume:61 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Harris Harley¹,Tao Lili²,Jacobs Emily B.¹,Bergman Yehudit¹,Adebayo Ayomikun¹,Tekle Tsigedera¹,Lewis Shawna¹,Dahlquist Ashley³,Abbey Taylor C.³,Wenzler Eric³,Humphries Romney²^ORCID,Simner Patricia J.¹^ORCID

Affiliation:

1. Department of Pathology, Division of Medical Microbiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

2. Department of Pathology, Microbiology, and Immunology, Division of Laboratory Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA

3. College of Pharmacy, University of Illinois Chicago, Chicago, Illinois, USA

Abstract

Due to limited therapeutic options, there is a clinical need to assess the in vitro activity of the combination of aztreonam (ATM) and ceftazidime-avibactam (CZA) to guide the therapeutic management of multidrug-resistant (MDR) Gram-negative organism infections. We set out to develop a practical MIC-based broth disk elution (BDE) method to determine the in vitro activity of the combination ATM-CZA using readily available supplies and compare it to reference broth microdilution (BMD).

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/jcm.01647-22

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