Epidemiology of β-Lactamase-Producing Pathogens

Author:

Bush Karen1ORCID,Bradford Patricia A.2ORCID

Affiliation:

1. Department of Biology, Indiana University, Bloomington, Indiana, USA

2. Antimicrobial Development Specialists, LLC, Nyack, New York, USA

Abstract

β-Lactam antibiotics have been widely used as therapeutic agents for the past 70 years, resulting in emergence of an abundance of β-lactam-inactivating β-lactamases. Although penicillinases in Staphylococcus aureus challenged the initial uses of penicillin, β-lactamases are most important in Gram-negative bacteria, particularly in enteric and nonfermentative pathogens, where collectively they confer resistance to all β-lactam-containing antibiotics.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology

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