Chronic Toxoplasma gondii Infection Induces Anti- N -Methyl- d -Aspartate Receptor Autoantibodies and Associated Behavioral Changes and Neuropathology-Reference-Cited by-同舟云学术

Chronic Toxoplasma gondii Infection Induces Anti- N -Methyl- d -Aspartate Receptor Autoantibodies and Associated Behavioral Changes and Neuropathology

Published:2018-10 Issue:10 Volume:86 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Li Ye¹,Viscidi Raphael P.²,Kannan Geetha³,McFarland Ross⁴,Pletnikov Mikhail V.⁴,Severance Emily G.¹,Yolken Robert H.¹,Xiao Jianchun¹

Affiliation:

1. Stanley Division of Developmental Neurovirology, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland, USA

2. Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland, USA

3. Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA

4. Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Abstract

Anti-NMDA receptor (NMDAR) autoantibodies have been postulated to play a role in the pathogenesis of NMDAR hypofunction, which contributes to the etiology of psychotic symptoms. Toxoplasma gondii is a pathogen implicated in psychiatric disorders and associated with elevation of NMDAR autoantibodies.

Funder

Stanley Medical Research Institute

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00398-18

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