Activity of compound G2 isolated from alfalfa roots against medically important yeasts

Author:

Polacheck I,Zehavi U,Naim M,Levy M,Evron R

Abstract

An antimycotic agent was isolated from roots of alfalfa and further purified to yield a nonhemolytic, homogeneous compound (G2). This compound contained considerable activity against 10 medically important yeasts. MICs obtained by both agar and broth dilution methods ranged from 3 to 15 micrograms/ml. Compound G2 was fungicidal at a relatively low concentration for nine different species of yeasts tested (minimum fungicidal concentrations ranged between 6 and 24 micrograms/ml). The considerable stability of compound G2 and its strong inhibitory and fungicidal activity against a broad range of yeasts suggest that after further development it might be useful as an active agent in the treatment of mycotic infections.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference26 articles.

1. Bennett J. E. 1985. Antifungal agents p. 263-270. In G. L. Mandell R. G. Douglas and J. E. Bennett (ed.) Principles and practice of infectious diseases 2nd ed. John Wiley & Sons Inc. New York.

2. Birk Y. and I. Peri. 1979. Saponins p. 161-182. In I. E. Leiner (ed.) Toxic constituents of plant foodstuffs 2nd ed. Academic Press Inc. New York.

3. Infections in cancer patients;Bodey G. P.;Cancer Treat. Rev.,1975

4. The saponins of Hedera helix with antibacterial activity;Cioaca C.;Pharmazie,1978

5. Densen P. and G. L. Mandell. 1979. Granulocytic phagocytes p. 63-82. In G. L. Mandell R. G. Douglas and J. E. Bennett (ed.) Principles and practice of Infectious Diseases. John Wiley & Sons Inc. New York.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3