Vancomycin Heteroresistance and Clinical Outcomes in Bloodstream Infections Caused by Coagulase-Negative Staphylococci-Reference-Cited by-同舟云学术

Vancomycin Heteroresistance and Clinical Outcomes in Bloodstream Infections Caused by Coagulase-Negative Staphylococci

Published:2020-10-20 Issue:11 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Dao Tina H.¹²,Alsallaq Ramzi¹,Parsons Joshua B.¹²,Ferrolino Jose¹,Hayden Randall T.²³^ORCID,Rubnitz Jeffrey E.²⁴,Rafiqullah Iftekhar M.⁵,Robinson D. Ashley⁵,Margolis Elisa B.¹²,Rosch Jason W.¹²^ORCID,Wolf Joshua¹²^ORCID

Affiliation:

1. Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA

2. University of Tennessee Health Science Center, Memphis, Tennessee, USA

3. Department of Pathology, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA

4. Department of Oncology, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA

5. Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, Mississippi, USA

Abstract

Coagulase-negative staphylococci (CoNS) are a common etiology of serious and recurrent infections in immunocompromised patients. Although most isolates appear susceptible to vancomycin, a single strain might have a subpopulation of resistant bacteria. This phenomenon is termed heteroresistance and may adversely affect the response to treatment. A retrospective cohort study was performed of pediatric patients with leukemia treated at St. Jude Children’s Research Hospital who developed CoNS central line-associated bloodstream infection (CLABSI).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00944-20

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