Vancomycin Heteroresistance in Bloodstream Isolates of Staphylococcus capitis

Author:

D'mello Danaë1,Daley Andrew J.23,Rahman Muhammad Shihab1,Qu Yue1,Garland Suzanne243,Pearce Christopher2,Deighton Margaret A.1

Affiliation:

1. School of Applied Sciences, RMIT University, Plenty Road, Bundoora, P.O. Box 71, Victoria 3083, Australia

2. Department of Microbiology, Royal Children's Hospital, Flemington Rd., Parkville, Victoria 3052, Australia

3. Department of Microbiology and Infectious Diseases, Royal Women's Hospital, Victoria, 132 Grattan St., Carlton, Victoria 3053, Australia

4. Department of Obstetrics and Gynaecology, University of Melbourne, Victoria 3010, Australia

Abstract

ABSTRACT Nine Staphylococcus capitis isolates from blood cultures of newborns were examined for resistance to vancomycin. MICs were within the susceptible range, but population profiling revealed a resistant subpopulation. Only isolates with the largest subpopulation were identified as heteroresistant to vancomycin by Etest. This finding may have therapeutic implications.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference22 articles.

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3. Bradford, R., R. Abdul Manan, A. J. Daley, C. Pearce, A. Ramalingam, D. D'mello, Y. Mueller, W. Uahwatanasakul, Y. Qu, D. Grando, S. Garland, and M. Deighton. 2006. Coagulase-negative staphylococci in very low birth weight infants: genetic markers do not distinguish invasive strains from blood culture contaminants. Eur. J. Clin. Microbiol. Infect. Dis.5:283-290.

4. Decreased Vancomycin Susceptibility of Coagulase-Negative Staphylococci in a Neonatal Intensive Care Unit: Evidence of Spread of Staphylococcus warneri

5. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically: approved standard 2006

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