Sindbis Macrodomain Poly-ADP-Ribose Hydrolase Activity Is Important for Viral RNA Synthesis-Reference-Cited by-全球学者库

Sindbis Macrodomain Poly-ADP-Ribose Hydrolase Activity Is Important for Viral RNA Synthesis

Published:2022-04-13 Issue:7 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Aguilar Eduardo G.¹,Paniccia Gabrielle¹,Adura Carolina²,Singer Zakary S.¹³,Ashbrook Alison W.¹,Razooky Brandon S.¹,Rice Charles M.¹,MacDonald Margaret R.¹^ORCID

Affiliation:

1. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, New York, USA

2. High-Throughput and Spectroscopy Resource Center, The Rockefeller University, New York, New York, USA

3. Department of Biomedical Engineering, Columbia University, New York, New York, USA

Abstract

Viral macrodomains have drawn attention in recent years due to their high degree of conservation in several virus families (e.g., coronaviruses and alphaviruses) and their potential druggability. These domains erase mono- or poly-ADP-ribose, posttranslational modifications written by host poly-ADP-ribose polymerase (PARP) proteins, from undetermined host or viral proteins to enhance replication.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01516-21

Reference54 articles.

1. What Pathogens Have Taught Us About Posttranslational Modifications

2. Arthritogenic alphaviruses—an overview

3. Sindbis Virus: A Newly Recognized Arthropod-Transmitted Virus 1

4. Active Infection of Human Blood Monocytes by Chikungunya Virus Triggers an Innate Immune Response

5. Sindbis viruses and other alphaviruses as cause of human arthritic disease

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Mutation of highly conserved residues in loop 2 of the coronavirus macrodomain demonstrates that enhanced ADP-ribose binding is detrimental to infection;2024-01-04

2. Macro1 domain residue F156: A hallmark of SARS-CoV-2 de-MARylation specificity;Virology;2023-10

3. Recurrent Loss of Macrodomain Activity in Host Immunity and Viral Proteins;Pathogens;2023-05-03

4. Metabolic Activation of PARP as a SARS-CoV-2 Therapeutic Target—Is It a Bait for the Virus or the Best Deal We Could Ever Make with the Virus? Is AMBICA the Potential Cure?;Biomolecules;2023-02-16