SARS-CoV-2 Causes Lung Infection without Severe Disease in Human ACE2 Knock-In Mice-Reference-Cited by-同舟云学术

SARS-CoV-2 Causes Lung Infection without Severe Disease in Human ACE2 Knock-In Mice

Published:2022-01-12 Issue:1 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Winkler Emma S.¹²,Chen Rita E.¹²,Alam Fahmida³⁴,Yildiz Soner³⁴,Case James Brett¹^ORCID,Uccellini Melissa B.³⁴,Holtzman Michael J.¹⁵,Garcia-Sastre Adolfo³⁴⁶⁷⁸^ORCID,Schotsaert Michael³⁴,Diamond Michael S.¹²⁹¹⁰

Affiliation:

1. Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA

2. Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA

3. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

4. Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA

5. Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, Missouri, USA

6. Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, USA

7. The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA

8. Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA

9. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

10. The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, Missouri, USA

Abstract

Mouse models of SARS-CoV-2 pathogenesis have facilitated the rapid evaluation of countermeasures. While the first generation of models developed pneumonia and severe disease after SARS-CoV-2 infection, they relied on ectopic expression of supraphysiological levels of human ACE2 (hACE2).

Funder

DOD | Defense Advanced Research Projects Agency

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01511-21

Reference50 articles.

1. SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

2. Protection of K18-hACE2 mice and ferrets against SARS-CoV-2 challenge by a single-dose mucosal immunization with a parainfluenza virus 5–based COVID-19 vaccine