Protection of K18-hACE2 mice and ferrets against SARS-CoV-2 challenge by a single-dose mucosal immunization with a parainfluenza virus 5–based COVID-19 vaccine-Reference-Cited by-同舟云学术

Protection of K18-hACE2 mice and ferrets against SARS-CoV-2 challenge by a single-dose mucosal immunization with a parainfluenza virus 5–based COVID-19 vaccine

Published:2021-07-02 Issue:27 Volume:7 Page:
ISSN:2375-2548
Container-title:Science Advances
language:en
Short-container-title:Sci. Adv.

Author:

An Dong¹^ORCID,Li Kun²,Rowe Dawne K.¹^ORCID,Diaz Maria Cristina Huertas¹,Griffin Emily F.¹^ORCID,Beavis Ashley C.¹^ORCID,Johnson Scott K.³^ORCID,Padykula Ian¹^ORCID,Jones Cheryl A.³^ORCID,Briggs Kelsey¹^ORCID,Li Geng¹^ORCID,Lin Yuan¹^ORCID,Huang Jiachen¹^ORCID,Mousa Jarrod¹³,Brindley Melinda¹^ORCID,Sakamoto Kaori⁴^ORCID,Meyerholz David K.⁵^ORCID,McCray Paul B.²⁶^ORCID,Tompkins S. Mark¹³^ORCID,He Biao¹^ORCID

Affiliation:

1. Department of Infectious Diseases, University of Georgia College of Veterinary Medicine, Athens, GA 30602, USA.

2. Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA.

3. Center for Vaccines and Immunology, University of Georgia College of Veterinary Medicine, Athens, GA 30602, USA.

4. Department of Pathology, University of Georgia College of Veterinary Medicine, Athens, GA 30602, USA.

5. Department of Pathology, University of Iowa, Iowa City, IA 52242, USA.

6. Department of Microbiology and Immunology, University of Iowa, Iowa City, IA 52242, USA.

Abstract

Single-dose intranasal COVID-19 vaccine prevents infection and inhibits transmission.

Funder

CyanVac LLC

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

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4. Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent Protection against SARS-CoV-2

5. Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

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