Tailoring the P450 Monooxygenase Gene for FR-008/Candicidin Biosynthesis-Reference-Cited by-同舟云学术

Tailoring the P450 Monooxygenase Gene for FR-008/Candicidin Biosynthesis

Published:2009-03-15 Issue:6 Volume:75 Page:1778-1781
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Chen Shi¹,Mao Xiangzhao²,Shen Yaling²,Zhou Yongjun¹,Li Jialiang¹,Wang Lianrong¹,Tao Xinyi²,Yang Liang²,Wang Yuxiao²,Zhou Xiufen¹,Deng Zixin¹,Wei Dongzhi²

Affiliation:

1. Laboratory of Microbial Metabolism and School of Life Science & Biotechnology, Shanghai Jiao Tong University, Shanghai 200030, People's Republic of China

2. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, People's Republic of China

Abstract

ABSTRACT Tailoring steps are often important for the activity of mature antibiotics. Here, we report that novel decarboxylated FR-008/candicidin derivatives were obtained from the P450 monooxygenase gene fscP mutant of Streptomyces sp. strain FR-008. The toxicity of decarboxylated FR-008/candicidin derivatives has been shown to be greatly reduced compared to that of wild-type FR-008/candicidin.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.00859-08

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