Antimicrobial Properties of Milk: Dependence on Presence of Xanthine Oxidase and Nitrite-Reference-Cited by-同舟云学术

Antimicrobial Properties of Milk: Dependence on Presence of Xanthine Oxidase and Nitrite

Published:2002-10 Issue:10 Volume:46 Page:3308-3310
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hancock John T.¹,Salisbury Vyv¹,Ovejero-Boglione Maria Cristina¹,Cherry Robert¹,Hoare Catherine²,Eisenthal Robert²,Harrison Roger²

Affiliation:

1. Centre for Research in Biomedicine, University of the West of England, Bristol, Bristol BS16 1QY

2. Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, United Kingdom

Abstract

ABSTRACT Human and bovine milk inhibited the metabolic activity of Escherichia coli , as shown by luminescence monitoring of constructs expressing the luxCDABE genes. Inhibition was dependent on both xanthine oxidase (XO) activity and on the presence of nitrite, implying that XO-generated nitric oxide functions as an antibacterial agent.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.46.10.3308-3310.2002

Reference25 articles.

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