A Bacterial Toxin Perturbs Intracellular Amino Acid Balance To Induce Persistence-Reference-Cited by-同舟云学术

A Bacterial Toxin Perturbs Intracellular Amino Acid Balance To Induce Persistence

Published:2021-02-23 Issue:1 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Zhou Xiaofeng¹²,Eckart Michael R.³,Shapiro Lucy²⁴^ORCID

Affiliation:

1. School of Agriculture, Sun Yat-sen University, Shenzhen, China

2. Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA

3. Stanford Protein and Nucleic Acid Facility, Stanford University School of Medicine, Stanford, California, USA

4. Chan Zuckerberg Biohub, San Francisco, California, USA

Abstract

To overcome various environmental challenges, bacterial cells can enter a physiologically quiescent state, known as dormancy or persistence, which balances growth and viability. In this study, we report a new mechanism by which a toxin-antitoxin system responds to harsh environmental conditions or nutrient deprivation by orchestrating a dormant state while preserving viability.

Funder

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.03020-20

Reference49 articles.

1. Bacterial Persisters and Infection: Past, Present, and Progressing

2. Persistent bacterial infections and persister cells

3. Bacterial Persistence