Roles of Ferredoxin-Dependent Proteins in the Apicoplast of Plasmodium falciparum Parasites-Reference-Cited by-同舟云学术

Roles of Ferredoxin-Dependent Proteins in the Apicoplast of Plasmodium falciparum Parasites

Published:2022-02-22 Issue:1 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Swift Russell P.¹,Rajaram Krithika¹,Elahi Rubayet¹^ORCID,Liu Hans B.¹,Prigge Sean T.¹^ORCID

Affiliation:

1. Department of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, Maryland, USA

Abstract

Ferredoxin (Fd) and ferredoxin-NADP+ reductase (FNR) form one of the few known redox systems in the apicoplast of malaria parasites and provide reducing power to iron-sulfur (FeS) cluster proteins within the organelle. While the Fd/FNR system has been explored as a drug target, the essentiality and roles of this system and the identity of its downstream FeS proteins have not been determined.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.03023-21

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