In silico modeling revealed phytomolecules derived from Cymbopogon citratus (DC.) leaf extract as promising candidates for malaria therapy

Author:

Evbuomwan Ikponmwosa Owen123ORCID,Alejolowo Omokolade Oluwaseyi12,Elebiyo Tobiloba Christiana2,Nwonuma Charles Obiora12,Ojo Oluwafemi Adeleke4ORCID,Edosomwan Evelyn Uwa5,Chikwendu Joy Ifeyinwa6,Elosiuba Nwanneka Victoria6,Akulue Justina Chimezie7,Dogunro Festus Ayorinde8,Rotimi Damilare Emmanuel12,Osemwegie Omorefosa Osarenkhoe3,Ojo Adebola Busola9,Ademowo Olusegun George1011,Adeyemi Oluyomi Stephen1212,Oluba Olarewaju Michael12

Affiliation:

1. SDG #03 Group – Good Health and Well-Being Research Cluster, Landmark University, Omu-Aran, Nigeria

2. Department of Biochemistry, Landmark University, Omu-Aran, Nigeria

3. Department of Food Science and Microbiology, Landmark University, Omu-Aran, Nigeria

4. Phytomedicine, Molecular Toxicology and Computational Biochemistry Research Group, Department of Biochemistry, Bowen University, Iwo, Nigeria

5. Department of Animal and Environmental Biology, University of Benin, Benin City, Nigeria

6. Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka, Nigeria

7. Department of Medical Laboratory Science, Nnamdi Azikiwe University, Awka, Nigeria

8. Federal Ministry of Health/National Arbovirus and Vectors Research Centre, Enugu, Nigeria

9. Department of Biochemistry, Ekiti State University, Ado-Ekiti, Nigeria

10. Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, University of Ibadan, Ibadan, Nigeria

11. Drug Research Laboratory, Institute of Advanced Medical Research and Training (IMRAT), College of Medicine, University of Ibadan, Ibadan, Nigeria

12. Laboratory of Sustainable Animal Environment, Graduate School of Agricultural Science, Tohoku University, Osaki, Miyagi, Japan

Funder

Royal Society for Tropical Medicine and Hygiene

Publisher

Informa UK Limited

Subject

Molecular Biology,General Medicine,Structural Biology

Reference115 articles.

1. Applications of Quantitative Structure-Activity Relationships (QSAR) based Virtual Screening in Drug Design: A Review

2. Plasmodium falciparum erythrocyte membrane protein 1 variants induce cell swelling and disrupt the blood–brain barrier in cerebral malaria

3. Ethanolic leaf extract of Psidium guajava: Phytochemical and trypanocidal activity in rats infected with Trypanosoma brucei brucei;Adeyemi O. S.;Journal of Medicinal Plants Research,,2009

4. Bacterial growth inhibition and antioxidant potentials of leaf infusions of (Moringa oleifera), locust beans (Parkia biglobosa) and bitter leaf (Vernonia amygladina)

5. Lipophilic efficiency as an important metric in the design of SARS coronavirus 3C-like proteinase (3CL-pro) inhibitors: Guidepost towards lead selection and optimization in the treatment of COVID-19;Ambrose G. O.;Drug Discovery,,2021

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