Restoring Herpesvirus Entry Mediator (HVEM) Immune Function in HVEM −/− Mice Rescues Herpes Simplex Virus 1 Latency and Reactivation Independently of Binding to Glycoprotein D-Reference-Cited by-同舟云学术

Restoring Herpesvirus Entry Mediator (HVEM) Immune Function in HVEM −/− Mice Rescues Herpes Simplex Virus 1 Latency and Reactivation Independently of Binding to Glycoprotein D

Published:2020-07-30 Issue:16 Volume:94 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Tormanen Kati¹,Wang Shaohui¹,Jaggi Ujjaldeep¹,Ghiasi Homayon¹^ORCID

Affiliation:

1. Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, Los Angeles, California, USA

Abstract

HSV-1 is a common cause of ocular infections worldwide and a significant cause of preventable blindness. Corneal scarring and blindness are consequences of the immune response induced by repeated reactivation events. Therefore, HSV-1 therapeutic approaches should focus on preventing latency and reactivation. Our data suggest that the immune function of HVEM plays an important role in the HSV-1 latency and reactivation cycle that is independent of HVEM binding to gD.

Funder

HHS | NIH | National Eye Institute

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00700-20

Reference69 articles.

1. Classification of Herpes Simplex Virus Keratitis and Anterior Uveitis

2. Herpes Simplex Virus Epidemiology and Ocular Importance

3. Epidemiology of Ocular Herpes Simplex