Characterization of Macrophage-Tropic HIV-1 Infection of Central Nervous System Cells and the Influence of Inflammation

Author:

Woodburn Blaide M.1,Kanchi Krishna2,Zhou Shuntai23ORCID,Colaianni Nicholas456,Joseph Sarah B.237,Swanstrom Ronald2389ORCID

Affiliation:

1. Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

2. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

3. Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

4. Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

5. Curriculum in Bioinformatics and Computational Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

6. Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

7. UNC HIV Cure Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

8. UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

9. Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

Abstract

The major feature of HIV-1 pathogenesis is the induction of an immunodeficient state in the face of an enhanced state of inflammation. However, for many of those infected, there can be an impact on the central nervous system (CNS) resulting in a wide range of neurocognitive defects.

Funder

HHS | NIH | National Institute on Drug Abuse

UNC Chapel Hill

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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