Whole-Genome Sequencing Reveals Diversity of Carbapenem-Resistant Pseudomonas aeruginosa Collected through CDC’s Emerging Infections Program, United States, 2016–2018

Author:

Stanton Richard A.1ORCID,Campbell Davina1,McAllister Gillian A.1,Breaker Erin1,Adamczyk Michelle1,Daniels Jonathan B.1,Lutgring Joseph D.1ORCID,Karlsson Maria1ORCID,Schutz Kyle2,Jacob Jesse T.34ORCID,Wilson Lucy E.5,Vaeth Elisabeth5,Li Linda5,Lynfield Ruth6,Snippes Vagnone Paula M.6,Phipps Erin C.78,Hancock Emily B.78,Dumyati Ghinwa9,Tsay Rebecca9,Cassidy P. Maureen10,Mounsey Jacquelyn11,Grass Julian E.1,Bulens Sandra N.1,Walters Maroya Spalding112,Halpin Alison Laufer112ORCID

Affiliation:

1. Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

2. Colorado Department of Public Health and Environment, Denver, Colorado, USA

3. Emory University School of Medicine, Atlanta, Georgia, USA

4. Georgia Emerging Infections Program, Atlanta, Georgia, USA

5. Maryland Department of Health, Baltimore, Maryland, USA

6. Minnesota Department of Health, St. Paul, Minnesota, USA

7. University of New Mexico, Albuquerque, New Mexico, USA

8. New Mexico Emerging Infections Program, Santa Fe, New Mexico, USA

9. New York Rochester Emerging Infections Program at the University of Rochester Medical Center, Rochester, New York, USA

10. Oregon Health Authority, Portland, Oregon, USA

11. Tennessee Department of Public Health, Nashville, Tennessee, USA

12. Commissioned Corps, U.S. Public Health Service, Rockville, Maryland, USA

Abstract

The CDC’s Emerging Infections Program (EIP) conducted population- and laboratory-based surveillance of US carbapenem-resistant Pseudomonas aeruginosa (CRPA) from 2016 through 2018. To characterize the pathotype, 1,019 isolates collected through this project underwent antimicrobial susceptibility testing and whole-genome sequencing.

Funder

HHS | Centers for Disease Control and Prevention

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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