Conserved Mechanisms of Mycobacterium marinum Pathogenesis within the Environmental Amoeba Acanthamoeba castellanii-Reference-Cited by-同舟云学术

Conserved Mechanisms of Mycobacterium marinum Pathogenesis within the Environmental Amoeba Acanthamoeba castellanii

Published:2012-03-15 Issue:6 Volume:78 Page:2049-2052
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Kennedy George M.¹,Morisaki J. Hiroshi²,DiGiuseppe Champion Patricia A.¹

Affiliation:

1. Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA

2. Program of Microbial Pathogenesis and Host Defense, University of California, San Francisco, California, USA

Abstract

ABSTRACT Mycobacterium marinum is a waterborne mycobacterial pathogen. Due to their common niche, protozoa likely represent natural hosts for M. marinum . We demonstrate that the ESX-1 secretion system is required for M. marinum pathogenesis and that M. marinum utilizes actin-based motility in amoebae. Therefore, at least two virulence pathways used by M. marinum in macrophages are conserved during M. marinum infection of amoebae.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.06965-11

Reference28 articles.

1. Survival of Environmental Mycobacteria in Acanthamoeba polyphaga

2. EsxA and EsxB are secreted by an ESAT-6-like system that is required for the pathogenesis of Staphylococcus aureus infections;Burts ML;Proc. Natl. Acad. Sci. U. S. A,2005

3. CangelosiGJC-C BehrM BullT StinearT. 2004. Biology of waterborne pathogenic mycobacteria, p 39–54. In PedleyS BartramJ ReesG DufourA CotruvoJA (ed), Pathogenic mycobacteria in water: a guide to public health consequences, monitoring and management. World Health Organization, Geneva, Switzerland.

4. Complex pattern of Mycobacterium marinum gene expression during long-term granulomatous infection;Chan K;Proc. Natl. Acad. Sci. U. S. A,2002

5. Growth of Legionella pneumophila in Acanthamoeba castellanii enhances invasion

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