Activity of Tigecycline or Colistin in Combination with Zidovudine against Escherichia coli Harboring tet (X) and mcr-1-Reference-Cited by-同舟云学术

Activity of Tigecycline or Colistin in Combination with Zidovudine against Escherichia coli Harboring tet (X) and mcr-1

Published:2020-12-16 Issue:1 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Zhou Yu-Feng¹²,Liu Ping¹²,Dai Shu-He¹²,Sun Jian¹²^ORCID,Liu Ya-Hong¹²,Liao Xiao-Ping¹²^ORCID

Affiliation:

1. National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

2. Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China

Abstract

Alternative therapeutic options are urgently needed against multidrug-resistant Escherichia coli infections, especially in situations of preexisting tigecycline and colistin resistance. Here, we investigated synergistic activity of the antiretroviral drug zidovudine in combination with tigecycline or colistin against E. coli harboring tet (X) and mcr-1 in vitro and in a murine thigh infection model. Zidovudine and tigecycline/colistin combinations achieved synergistic killing and significantly decreased bacterial burdens by >2.

Funder

National Key Research and Development Program of China

Program for Innovative Research Team in the University of Ministry of Education of China

Foundation for Innovation and Strengthening School Project of Guangdong, China

Guangdong Special Support Program Innovation Team

Innovation Team Project of Guangdong University

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01172-20