Abstract
Colistin is a last-line antibiotic against Gram-negative pathogens. However, the emergence of colistin resistance has substantially reduced the clinical effectiveness of colistin. In this study, synergy between colistin and capric acid was examined against twenty-one Gram-negative bacterial isolates (four colistin-susceptible and seventeen colistin-resistant). Checkerboard assays showed a synergistic effect against all colistin-resistant strains [(FICI, fractional inhibitory concentration index) = 0.02–0.38] and two colistin-susceptible strains. Time–kill assays confirmed the combination was synergistic. We suggest that the combination of colistin and capric acid is a promising therapeutic strategy against Gram-negative colistin-resistant strains.
Funder
the National Natural Science Foundation of China
Science and Technology Program of Guangzhou
Project of Educational Commission of Guangdong Province of China
Science and Technology Program of Guangzhou, China
the Innovation Team Project of Guangdong University
the 111 Project
National Natural Science Foundation of China
Subject
Pharmacology (medical),Infectious Diseases,Microbiology (medical),General Pharmacology, Toxicology and Pharmaceutics,Biochemistry,Microbiology
Reference28 articles.
1. Antimicrobial Resistance in ESKAPE Pathogens;Forde;Clin. Microbiol. Rev.,2020
2. Emergence of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae;Du;Lancet Infect. Dis.,2016
3. Trends in carbapenemase-producing Enterobacteriaceae, France, 2012 to 2014;Dortet;Eurosurveillance,2017
4. New Delhi metallo-beta-lactamase-1-producing Acinetobacter spp. infection: Report of a survivor;Schmitt;Rev. Soc. Bras. Med. Trop.,2016
5. What remains against carbapenem-resistant Enterobacteriaceae? Evaluation of chloramphenicol, ciprofloxacin, colistin, fosfomycin, minocycline, nitrofurantoin, temocillin and tigecycline;Livermore;Int. J. Antimicrob. Agents,2011
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