The Myeloid-Specific Transcription Factor PU.1 Upregulates Mannose Receptor Expression but Represses Basal Activity of the HIV-LTR Promoter-Reference-Cited by-同舟云学术

The Myeloid-Specific Transcription Factor PU.1 Upregulates Mannose Receptor Expression but Represses Basal Activity of the HIV-LTR Promoter

Published:2022-07-27 Issue:14 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Kao Sandra¹,Miyagi Eri¹,Mallorson Rosa¹,Saito Hideki¹,Sukegawa Sayaka²,Mukherji Abhik¹,Mateja Allyson³,Ferhadian Damien¹,Fabryova Helena¹,Clouse Kathleen⁴,Strebel Klaus¹^ORCID

Affiliation:

1. Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA

2. Tokyo Medical and Dental University, Department of Molecular Virology, Tokyo, Japan

3. Clinical Monitoring Research Program Directorate; Frederick National Laboratory, Frederick, Maryland, USA

4. Division of Biotechnology Review and Research 1, Office of Biotechnology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA

Abstract

HIV-1 replication in primary human cells depends on the activity of virus-encoded proteins but also involves cellular factors that can either promote (viral dependency factors) or inhibit (host restriction factors) virus replication. In previous work, we identified human MRC1 as a macrophage-specific host restriction factor that inhibits the detachment of viral particles from infected cells.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00652-22

Reference53 articles.

1. An Interferon-α-Induced Tethering Mechanism Inhibits HIV-1 and Ebola Virus Particle Release but Is Counteracted by the HIV-1 Vpu Protein

2. The Interferon-Induced Protein BST-2 Restricts HIV-1 Release and Is Downregulated from the Cell Surface by the Viral Vpu Protein

3. Mannose Receptor 1 Restricts HIV Particle Release from Infected Macrophages