Affiliation:
1. Welsh School of Pharmacy, University of Wales College of Cardiff.
Abstract
Bacterial spores are among the most resistant of all living cells to biocides, although the response depends on the stage of sporulation. The development of resistance to some agents such as chlorhexidine occurs much earlier in sporulation than does resistance to glutaraldehyde, which is a very late event. During germination or outgrowth or both, resistance is lost and the cells become as susceptible to biocides as nonsporulating bacteria. Mechanisms of spore resistance to, and the action of, biocides are discussed, and possible means of enhancing antispore activity are considered. The clinical and other uses of sporicidal and sporostatic chemical agents are described.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology
Reference243 articles.
1. Sporicidal activity of local anesthetics and their binary combinations with preservatives;Abdelaziz A. A.;J. Clin. Pharm. Ther.,1988
2. Studies on germination of spores of clostridial strains capable of causing food poisoning. II. Effects of some chemicals on the germination of spores of Clostridium botulinum Type A (in Japanese);Ando Y.;J. Food Hyg. Soc. Jpn.,1973
3. Mechanism of nitrite-induced germination of Clostridium perfringens spores;Ando Y.;J. Appl. Bacteriol.,1980
4. The effect of hydrogen peroxide on spores of Clostridium perfringens;Ando Y.;Lett. Appl. Microbiol.,1986
5. Changes in decoated spores of Clostridium perfringens caused by treatment with some enzymatic and non-enzymatic systems;Ando Y.;Lett. Appl. Microbiol.,1986
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