New Structure Model for the Packaging Signal in the Genome of Group IIa Coronaviruses-Reference-Cited by-同舟云学术

New Structure Model for the Packaging Signal in the Genome of Group IIa Coronaviruses

Published:2007-06-15 Issue:12 Volume:81 Page:6771-6774
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Chen Shih-Cheng¹,van den Born Erwin²,van den Worm Sjoerd H. E.²,Pleij Cornelis W. A.¹,Snijder Eric J.²,Olsthoorn René C. L.¹

Affiliation:

1. Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands

2. Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands

Abstract

ABSTRACT A 190-nucleotide (nt) packaging signal (PS) located in the 3′ end of open reading frame 1b in the mouse hepatitis virus, a group IIa coronavirus, was previously postulated to direct genome RNA packaging. Based on phylogenetic data and structure probing, we have identified a 95-nt hairpin within the 190-nt PS domain which is conserved in all group IIa coronaviruses but not in the severe acute respiratory syndrome coronavirus (group IIb), group I coronaviruses, or group III coronaviruses. The hairpin is composed of six copies of a repeating structural subunit that consists of 2-nt bulges and 5-bp stems. We propose that repeating AA bulges are characteristic features of group IIa PSs.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02231-06

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