Microbiological Transformation of Enrofloxacin by the Fungus Mucor ramannianus-Reference-Cited by-同舟云学术

Microbiological Transformation of Enrofloxacin by the Fungus Mucor ramannianus

Published:2000-06 Issue:6 Volume:66 Page:2664-2667
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Parshikov Igor A.¹,Freeman James P.²,Lay Jackson O.²,Beger Richard D.²,Williams Anna J.¹,Sutherland John B.¹

Affiliation:

1. Division of Microbiology1 and

2. Division of Chemistry,2 National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079

Abstract

ABSTRACT Enrofloxacin metabolism by Mucor ramannianus was investigated as a model for the biotransformation of veterinary fluoroquinolones. Cultures grown in sucrose-peptone broth were dosed with enrofloxacin. After 21 days, 22% of the enrofloxacin remained. Three metabolites were identified: enrofloxacin N -oxide (62% of the total absorbance), N -acetylciprofloxacin (8.0%), and desethylene-enrofloxacin (3.5%).

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/AEM.66.6.2664-2667.2000

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