Unique Features of Alarmone Metabolism in Clostridioides difficile

Author:

Poudel Asia1,Pokhrel Astha1,Oludiran Adenrele1,Coronado Estevan J.1,Alleyne Kwincy1,Gilfus Marrett M.1,Gurung Raj K.1,Adhikari Surya B.1,Purcell Erin B.1ORCID

Affiliation:

1. Old Dominion University, Department of Chemistry and Biochemistry, Norfolk, Virginia, USA

Abstract

Despite the role of the stringent response in antibiotic survival and recurrent infections, it has been a challenging target for antibacterial therapies because it is so ubiquitous. This is an especially relevant consideration for the treatment of Clostridioides difficile infection (CDI), as exposure to broad-spectrum antibiotics that harm commensal microbes is a major risk factor for CDI.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

National Science Foundation

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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