Host-Derived Metabolites Modulate Transcription of Salmonella Genes Involved in l -Lactate Utilization during Gut Colonization

Abstract

During Salmonella enterica serovar Typhimurium infection, host inflammation alters the metabolic environment of the gut lumen to favor the outgrowth of the pathogen at the expense of the microbiota. Inflammation-driven changes in host cell metabolism lead to the release of l -lactate and molecular oxygen from the tissue into the gut lumen.