B Cell Compartmentalization in Blood and Cerebrospinal Fluid of HIV-Infected Ugandans with Cryptococcal Meningitis

Author:

Okurut Samuel123ORCID,Meya David B.145,Bwanga Freddie2,Olobo Joseph6,Eller Michael A.78,Cham-Jallow Fatim378,Bohjanen Paul R.5,Pratap Harsh9,Palmer Brent E.9,Hullsiek Katharine H.5,Manabe Yukari C.110,Boulware David R.5,Janoff Edward N.911

Affiliation:

1. Research Department, Infectious Diseases Institute, Makerere University, Kampala, Uganda

2. Department of Microbiology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda

3. Laboratory Department, Makerere University Walter Reed Project, Kampala, Uganda

4. Department of Medicine, School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda

5. Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA

6. Department of Immunology and Molecular Biology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda

7. U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA

8. Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA

9. Mucosal and Vaccine Research Program Colorado, Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA

10. Division of Infectious Diseases, Department of Medicine, John Hopkins University School of Medicine, Baltimore, Maryland, USA

11. Denver Veterans Affairs Medical Center, Denver, Colorado, USA

Abstract

Activated B cells modulate infection by differentiating into pathogen-specific antibody-producing effector plasmablasts/plasma cells, memory cells, and immune regulatory B cells. In this context, the B cell phenotypes that infiltrate the central nervous system during human immunodeficiency virus (HIV) and cryptococcal meningitis coinfection are ill defined.

Funder

HHS | NIH | Fogarty International Center

GlaxoSmithKline

Henry M. Jackson Foundation

HHS | NIH | NIH Blueprint for Neuroscience Research

VA | Veterans Affairs San Diego Healthcare System

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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