D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Virus Titer via Enhanced Furin-Mediated Spike Cleavage-Reference-Cited by-同舟云学术

D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Virus Titer via Enhanced Furin-Mediated Spike Cleavage

Published:2021-08-31 Issue:4 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Cheng Ya-Wen¹,Chao Tai-Ling²,Li Chiao-Ling¹,Wang Sheng-Han³,Kao Han-Chieh²,Tsai Ya-Min²,Wang Hurng-Yi⁴,Hsieh Chi-Ling¹,Lin You-Yu⁴,Chen Pei-Jer⁴⁵⁶,Chang Sui-Yuan²⁷^ORCID,Yeh Shiou-Hwei¹²⁶^ORCID

Affiliation:

1. Department of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan

2. Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan

3. Hepatitis Research Center, National Taiwan University Hospital, Taipei, Taiwan

4. Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan

5. Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

6. National Taiwan University Center for Genomic Medicine, National Taiwan University College of Medicine, Taipei, Taiwan

7. Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan

Abstract

Analysis of viral genomes and monitoring of the evolutionary trajectory of SARS-CoV-2 over time has identified the D614G substitution in spike (S) as the most prevalent expanding variant worldwide, which might confer a selective advantage in transmission. Several studies showed that the D614G variant replicates and transmits more efficiently than the wild-type virus, but the mechanism is unclear.

Funder

Ministry of Science and Technology, Taiwan

Ministry of Education (MOE), Higher Education Sprout Project, Taiwan

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00587-21

Reference39 articles.

1. Genomics insights of SARS-CoV-2 (COVID-19) into target-based drug discovery

2. Mechanisms of viral mutation