The harms of promoting the lab leak hypothesis for SARS-CoV-2 origins without evidence

Author:

Alwine James12ORCID,Goodrum Felicia1ORCID,Banfield Bruce3ORCID,Bloom David4ORCID,Britt William J.5,Broadbent Andrew J.6ORCID,Campos Samuel K.1ORCID,Casadevall Arturo7ORCID,Chan Gary C.8ORCID,Cliffe Anna R.9,Dermody Terence10ORCID,Duprex Paul11ORCID,Enquist Lynn W.112ORCID,Frueh Klaus13,Geballe Adam P.14ORCID,Gaglia Marta15ORCID,Goldstein Stephen1617,Greninger Alexander L.18,Gronvall Gigi Kwick7ORCID,Jung Jae U.19ORCID,Kamil Jeremy P.20ORCID,Lakdawala Seema21ORCID,Liu Shan-Lu22ORCID,Luftig Micah23ORCID,Moore John P.24ORCID,Moscona Anne25ORCID,Neuman Benjamin W.26ORCID,Nikolich Janko Ž.1ORCID,O'Connor Christine19ORCID,Pekosz Andrew7ORCID,Permar Sallie27ORCID,Pfeiffer Julie28ORCID,Purdy John1ORCID,Rasmussen Angela29ORCID,Semler Bert30ORCID,Smith Gregory A.31ORCID,Stein David A.32,Van Doorslaer Koenraad1,Weller Sandra K.33ORCID,Whelan Sean P. J.34ORCID,Yurochko Andrew20ORCID

Affiliation:

1. Department of Immunobiology, University of Arizona, Tucson, Arizona, USA

2. University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA

3. Department of Biomedical and Molecular Sciences, Queens University, Kingston, Ontario, Canada

4. Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, USA

5. Department of Pediatrics, University of Alabama, Birmingham, Birmingham, Alabama, USA

6. Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA

7. Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, USA

8. Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, New York, USA

9. Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, USA

10. Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

11. University of Pittsburgh, Center for Vaccine Research, Pittsburgh, Pennsylvania, USA

12. Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA

13. Oregon Health and Science University, Vaccine and Gene Therapy Institute, Beaverton, Oregon, USA

14. Department of Medicine, University of Washington, Fred Hutchinson Cancer Center, Seattle, Washington, USA

15. Department of Medical Microbiology and Immunology, University of Wisconsin, Institute for Molecular Virology, Madison, Wisconsin, USA

16. Department of Human Genetics, University of Utah School of Medicine, Howard Hughes Medical Institute, Salt Lake City, Utah, USA

17. Howard Hughes Medical Institute, Chevy Chase, Maryland, USA

18. Department of Medicine, Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA

19. Cleveland Clinic, Lerner Research Institute, Cleveland, Ohio, USA

20. Department of Microbiology and Immunology, Louisiana State University Health Sciences, Shreveport, Louisiana, USA

21. Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA

22. The Ohio State University, Center for Retrovirus Research and Infectious Disease Institute, Columbus, Ohio, USA

23. Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA

24. Department of Microbiology and Immunology, Cornell University, Weill Cornell Medicine, New York, New York, USA

25. Columbia University, Vagelos College of Physicians and Surgeons, New York, New York, USA

26. Department of Biology, Texas A&M University, College Station, Texas, USA

27. Department of Pediatrics, Cornell University, Weill Cornell Medicine, New York, New York, USA

28. University of Texas, Southwestern Medical Center, Dallas, Texas, USA

29. University of Saskatchewan, College of Medicine, Saskatoon, Canada

30. Department of Microbiology and Molecular Genetics, University of California, Irvine, Irvine, California, USA

31. Department of Microbiology and Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA

32. Oregon State University, Carlson College of Veterinary Medicine, Corvallis, Oregon, USA

33. Department of Molecular Biology and Biophysics, University of Connecticut, Farmington, Connecticut, USA

34. Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA

Abstract

ABSTRACT Science is humanity’s best insurance against threats from nature, but it is a fragile enterprise that must be nourished and protected. The preponderance of scientific evidence indicates a natural origin for SARS-CoV-2. Yet, the theory that SARS-CoV-2 was engineered in and escaped from a lab dominates media attention, even in the absence of strong evidence. We discuss how the resulting anti-science movement puts the research community, scientific research, and pandemic preparedness at risk.

Publisher

American Society for Microbiology

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