Structural Study of Aavrh.10 Receptor and Antibody Interactions

Author:

Mietzsch Mario1,Yu Jennifer C.1,Hsi Jane1,Chipman Paul1,Broecker Felix23,Fuming Zhang4,Linhardt Robert J.4,Seeberger Peter H.23,Heilbronn Regine5,McKenna Robert1ORCID,Agbandje-McKenna Mavis1ORCID

Affiliation:

1. Department of Biochemistry and Molecular Biology, Center for Structural Biology, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, Florida, USA

2. Department of Biomolecular Systems, Max-Planck Institute of Colloids and Interfaces, Potsdam, Germany

3. Institute of Chemistry and Biochemistry, Freie Universität Berlin, Berlin, Germany

4. Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York, USA

5. Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany

Abstract

Gene therapy vectors based on adeno-associated virus rhesus isolate 10 (AAVrh.10) have been used in several clinical trials to treat monogenetic diseases. However, compared to other AAV serotypes little is known about receptor binding and antigenicity of the AAVrh.10 capsid.

Funder

Deutsche Forschungsgemeinschaft

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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