Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation-Reference-Cited by-同舟云学术

Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation

Published:2021-12-21 Issue:6 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Hammam Elie¹²³,Sinha Ameya⁴⁵⁶,Baumgarten Sebastian¹²³^ORCID,Nardella Flore¹²³,Liang Jiaqi⁴⁵⁶,Miled Samia⁷⁸,Bonhomme Frédéric⁹,Erdmann Diane⁹¹⁰,Arcangioli Benoit¹¹,Arimondo Paola B.⁹,Dedon Peter⁴⁵,Preiser Peter⁴⁶,Scherf Artur¹²³^ORCID

Affiliation:

1. Biology of Host-Parasite Interaction, Institut Pasteur, Paris, France

2. CNRS ERL9195, Paris, France

3. INSERM U1201, Paris, France

4. Antimicrobial Resistance Interdisciplinary Research Group, Singapore-MIT Alliance for Research and Technology, Singapore, Singapore

5. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

6. School of Biological Sciences, Nanyang Technological University, Singapore, Singapore

7. Université de Paris, CNRS, Institut Jacques Monod, Paris, France

8. École technique supérieure du Laboratoire, Paris, France

9. Epigenetic Chemical Biology, Institut Pasteur, UMR 3523, CNRS, France

10. Ecole Doctorale MTCI ED563, Université de Paris, Sorbonne Paris Cité, Paris, France

11. Genome Dynamics Unit, Institut Pasteur, UMR 3525, CNRS, Paris, France

Abstract

P. falciparum is the most virulent malaria parasite species, accounting for the majority of the disease mortality and morbidity. Understanding how this pathogen is able to adapt to different cellular and environmental stressors during its complex life cycle is crucial in order to develop new strategies to tackle the disease.

Funder

French parasitology consortium

Fondation Pasteur Swiss

Agence Nationale de la Recherche

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02558-21

Reference57 articles.

1. WHO. 2020. World malaria report. WHO, Geneva, Switzerland.