GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing-Reference-Cited by-同舟云学术

GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing

Published:2018-03-16 Issue:6381 Volume:359 Page:1259-1263
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Filarsky Michael¹²^ORCID,Fraschka Sabine A.³^ORCID,Niederwieser Igor¹²,Brancucci Nicolas M. B.¹²^ORCID,Carrington Eilidh¹²^ORCID,Carrió Elvira¹²^ORCID,Moes Suzette⁴,Jenoe Paul⁴,Bártfai Richárd³^ORCID,Voss Till S.¹²^ORCID

Affiliation:

1. Swiss Tropical and Public Health Institute, 4051 Basel, Switzerland.

2. University of Basel, 4003 Basel, Switzerland.

3. Department of Molecular Biology, Radboud University, 6525 GA Nijmegen, Netherlands.

4. Biozentrum, University of Basel, 4056 Basel, Switzerland.

Abstract

Sexual development in Plasmodium Malaria-causing parasites ( Plasmodium ) have complex life histories in the tissues of humans. For the most part, the parasites focus their efforts on replication within the human host cells. However, occasionally, some replicating cells release gametes into the bloodstream, which are picked up by biting mosquitoes. Filarsky et al. discovered that the Plasmodium parasite keeps the production of gametes under tight epigenetic control using heterochromatin protein 1 (HP1). Plasmodium gametocytogenesis is initiated when HP1 is evicted from upstream of gamete-specific genes by gametocyte development 1 (GDV1) protein. GDV1 is in turn regulated by its antisense RNA. What triggers GDV1 expression remains unclear. Elucidating this pathway could provide a target for interrupting malaria transmission. Science , this issue p. 1259

Funder

Swiss National Science Foundation

Netherlands Organization for Scientific Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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