Secretion of and Self-Resistance to the Novel Fibupeptide Antimicrobial Lugdunin by Distinct ABC Transporters in Staphylococcus lugdunensis-Reference-Cited by-同舟云学术

Secretion of and Self-Resistance to the Novel Fibupeptide Antimicrobial Lugdunin by Distinct ABC Transporters in Staphylococcus lugdunensis

Published:2020-12-16 Issue:1 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Krauss Sophia¹²³,Zipperer Alexander¹²,Wirtz Sebastian³⁴,Saur Julian³⁴,Konnerth Martin C.³⁴,Heilbronner Simon¹²³,Torres Salazar Benjamin O.¹²³,Grond Stephanie³⁴,Krismer Bernhard¹²³^ORCID,Peschel Andreas¹²³^ORCID

Affiliation:

1. Interfaculty Institute of Microbiology and Infection Medicine, Infection Biology, University of Tübingen, Tübingen, Germany

2. German Center for Infection Research (DZIF), Tübingen, Germany

3. Cluster of Excellence: EXC 2124: Controlling Microbes to Fight Infection, Tübingen, Germany

4. Institute of Organic Chemistry, University of Tübingen, Tübingen, Germany

Abstract

Lugdunin is the first reported nonribosomally synthesized antibiotic from human microbiomes. Its production by the commensal Staphylococcus lugdunensis eliminates the pathogen Staphylococcus aureus from human nasal microbiomes. The cycloheptapeptide lugdunin is the founding member of the new class of fibupeptide antibiotics, which have a novel mode of action and represent promising new antimicrobial agents. How S. lugdunensis releases and achieves producer self-resistance to lugdunin has remained unknown.

Funder

Deutsche Forschungsgemeinschaft

Deutsches Zentrum für Infektionsforschung

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01734-20

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