Discovery of Antimicrobial Phosphonopeptide Natural Products from Bacillus velezensis by Genome Mining-Reference-Cited by-同舟云学术

Discovery of Antimicrobial Phosphonopeptide Natural Products from Bacillus velezensis by Genome Mining

Published:2023-06-28 Issue:6 Volume:89 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Wilson Jake¹²,Cui Jerry¹^ORCID,Nakao Toshiki¹,Kwok Happy¹,Zhang Yeying¹,Kayrouz Chase M.¹,Pham Tiffany M.¹,Roodhouse Hannah¹,Ju Kou-San¹²³⁴^ORCID

Affiliation:

1. Department of Microbiology, The Ohio State University, Columbus, Ohio, USA

2. Division of Medicinal Chemistry and Pharmacognosy, The Ohio State University, Columbus, Ohio, USA

3. Center for Applied Plant Sciences, The Ohio State University, Columbus, Ohio, USA

4. Infectious Diseases Institute, The Ohio State University, Columbus, Ohio, USA

Abstract

Phosphonate natural products produced by bacteria have been a rich source of clinical antibiotics and commercial pesticides. Here, we describe the discovery of two new phosphonopeptides produced by B. velezensis with antibacterial activity against human and plant pathogens, including those responsible for widespread soft rot in crops and American foulbrood.

Funder

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/aem.00338-23

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