Chemokine CCL28 Is a Potent Therapeutic Agent for Oropharyngeal Candidiasis

Author:

He Jie1,Thomas Monica A.2,de Anda Jaime3,Lee Michelle W.3,Van Why Emma1,Simpson Pippa4,Wong Gerard C. L.3,Grayson Mitchell H.56,Volkman Brian F.2,Huppler Anna R.1

Affiliation:

1. Department of Pediatrics, Division of Infectious Disease, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

2. Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

3. Department of Bioengineering, University of California, Los Angeles, Los Angeles, California, USA

4. Department of Pediatrics, Division of Quantitative Health Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

5. Department of Pediatrics, Division of Allergy and Immunology, The Ohio State University College of Medicine, Columbus, Ohio, USA

6. The Abigail Wexner Research Institute, Nationwide Children’s Hospital, Columbus, Ohio, USA

Abstract

Candida albicans is a commensal organism that causes life-threatening or life-altering opportunistic infections. Treatment of Candida infections is limited by the paucity of antifungal drug classes. Naturally occurring antimicrobial peptides are promising agents for drug development. CCL28 is a CC chemokine that is abundant in saliva and has in vitro antimicrobial activity. In this study, we examine the in vivo Candida killing capacity of CCL28 in oropharyngeal candidiasis as well as the spectrum and mechanism of anti- Candida activity.

Funder

Medical College of Wisconsin Department of Pediatrics

HHS | National Institutes of Health

National Science Foundation

National Psoriasis Foundation

Children's Hospital of Wisconsin Research Institute

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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